Huntington's Disease
Brain Organoids for HD Research
Using patient-derived and embryonic stem-cell brain organoids, we model Huntington’s disease, replicating its neurodevelopmental and neurodegenerative properties.
Electrophysiology in Brain Organoids
We analyse neuronal excitability and network function in Huntington’s disease organoids, identifying disease-specific changes
Cellular Models of HTT
Our research focuses on how mutant HTT proteins impact cellular function, using advanced cellular models.
Lu, M., Banetta, L., Young, L.J., Smith, E.J., Bates, G.P., Zaccone, A., Schierle, G.S.K., Tunnacliffe, A. and Kaminski, C.F., 2019. Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly. Journal of Biological Chemistry, 294(1), pp.257-268.
PEDOT:PSS Flexible Devices and Software
We integrate flexible electronic devices with brain organoids to enhance electrophysiological recordings and study network behaviour.
Collaborations
Our Huntington’s research is strengthened through global collaborations with experts in brain organoid, HD, and electrophysiology, including with Dr Madeline Lancaster (MRC Laboratory of Molecular Biology, UK), Prof. Gill Bates (University College London, UK), and Prof. Ole Paulsen (University of Cambridge, UK).